While current evidence suggests that you can have no back pain with disc herniation, it may still be a major contributor to back pain due to various biological processes that you and your therapist should not ignore.

In 2015, many physical and massage therapists on social media were excited about a study that concluded disc herniation and other physical “abnormalities” of the spine are “part of normal aging and unassociated with low back pain.” (1) Published in the American Journal of Neuroradiology, the researchers found that “thirty percent of those in their twenties had bulging disc, compared to 84 percent among subjects in their eighties,” based on a review of 33 studies with a total of 3,110 subjects with no pain.

This seems like great news for both therapists and patients. No surgery is necessary. No “fixing” required. However, we should not dismiss the biological contributions and evidence for disc herniation and back pain since biology is still pretty relevant in the biopsychosocial model of pain.

There is no strong evidence that massage therapy can guarantee pain relief from a herniated disc or typical low back pain. (2) However, given that pain is a complex experience—not just caused by biological factors themselves—massage may provide some degree of pain relief from the analgesic effects of touch. (3) It is quite a dilemma. While current scientific evidence says, “Not really,” some people’s experiences counter, “Yes, it works!”

The strongest evidence so far is that massage therapy may alleviate low back pain from disc herniation via descending modulation, a process that involves how your brain interprets sensory stimulation and environmental cues to predict whether you are safe or not. (3) To sort out the mess, we should examine what we know about disc herniation in relation to pain and massage.

How Could Disc Herniation Contribute to Back Pain?

If you had visited your physician or physical therapist, you may have seen a model of the lumbar spine sitting on the counter with jelly-like discs that you can remove and slip them back in like a Jenga game. Sometimes these discs can bulge and compress against a spinal nerve that may cause pain in the lower back or down on one leg. Thus, the current evidence indicates that disc herniation is not as simple as just a nerve compression to cause back pain.

Gene expression and herniated disc

In the past 15 years, many research revealed that certain genes may be risk factors for disc degeneration, including disc herniation. (4,5,6) Some of these genes are assigned numbers similar to stormtroopers in the Star Wars universe. Two of these genes, called COL9A2 and COL9A3, are encoded in a larger protein chain called Collagen IX, which connects collagenous and non-collagenous proteins in various human tissues. However, a recent systematic review and meta-analysis from Guangxi Medical University in China found such risk factors are not that significant. (7)

Compared to previous reviews, this one pooled data from 10 qualified case-control studies from Finland, India, and various East Asian countries that were more recent and were not included in the recent review. With a total of 2,102 cases and 2,507 controls, they found “no statistically significant association” between the COL9A2 and COL9A3 genes and risk of lumbar disc degeneration.

Even with this finding, the authors pointed out that the studies they gathered had different methods of testing, which may affect the quality of their conclusion. These include diagnostic criteria for disc degeneration, study design, environmental factors, and language bias (English and Chinese studies were included in this review). (7) This does not mean genetic factors are not potential contributors to disc herniation and back pain. The positive findings of these genes may not be as strong as some researchers and clinicians believe.

herniated disc massage

Image: Anatomy & Physiology, Connexions Web site. http://cnx.org/content/col11496/1.6/

Inflammation and bacteria in disc herniation

In a herniated disc, the center part of the intervertebral disc—nucleus pulposus—extrudes into the epidural space, the gap between the vertebrae and dura matter. This increases permeability in the blood vessels in the space, allowing inflammatory proteins and markers to concentrate in the area. Since the nucleus pulposus contains 70 to 90 percent water among most people in their twenties and thirties, this amount gradually decreases with age, a sign of “degeneration.” (10)

Such reductions in disc size has been shown to increase acidity in the discs, which may be caused by reduced metabolic exchange (e.g. exchange of electrolytes between a cell and its fluid environment). This has been shown to inhibit cell formation while increases the number of cell deaths in the nucleus pulposus. (11,12,13)

Inflammation can also be caused by Propionibacterium acnes, a Gram-positive bacteria that has been shown to correlate with patients with disc herniation. (9) However, the evidence is pretty weak, according to a recent systematic review that stated, “ …we cannot support that P. acnes and development of symptomatic degenerative disc disease due to the low quality of the results….” (8)

While massage therapy cannot change your genes, “push” a disc back in place, or squeegee bacteria out of your body, it may alleviate the symptoms caused by these factors, similar to most types of low back pain. But be aware that such “degeneration” may not be a significant cause of back pain for some people since research has shown that many older adults with this degeneration are asymptomatic. (1)

Research has yet to reveal why some people have no pain with a disc herniation while some do. Perhaps there is something going on in the brain that affects individual pain tolerance? Maybe those with a disc herniation and no pain have a healthy lifestyle (e.g. good diet and exercise habits) that suppresses the inflammatory signals? Or could it be that disc herniation just does not elicit symptoms for some people? For a few lucky folks, a herniated disc could reabsorb back into its place without any interventions! (14,15)

With the lack the quality research that examines whether massage therapy could help alleviate back pain symptoms due to disc hernia, the best evidence we can fall back on currently is the biopsychosocial model of pain and narrative medicine. The principles behind them can guide therapists and patients on the best approach to less pain and disability and more independence and locus of control.

 

References

1. Brinjikji W, Luetmer PH, Comstock B, et al. Systematic literature review of imaging features of spinal degeneration in asymptomatic populations. AJNR Am J Neuroradiol. 2015;36(4):811–816. doi:10.3174/ajnr.A4173.

2. Furlan AD, Giraldo M, Baskwill A, Irvin E, Imamura M. Massage for low-back pain. Cochrane Database Syst Rev. 2015 Sep 1;(9):CD001929. doi: 10.1002/14651858.CD001929.pub3.

3. Vigotsky A, Bruhns P. The role of descending modulation in manual therapy and its analgesic implications: a narrative review. In Pain Research and Treatment. 2015(9):292805. doi: 10.1155/2015/292805.

4. Janeczko Ł, Janeczko M, Chrzanowski R, Zieliński G. The role of polymorphisms of genes encoding collagen IX and XI in lumbar disc disease. Neurol Neurochir Pol. 2014 Jan-Feb;48(1):60-2. doi: 10.1016/j.pjnns.2013.04.001. Epub 2014 Jan 23.

5. Zhang Z, Zhang J, Ding L, Teng X. Meta-analysis of the association between COL9A2 genetic polymorphisms and lumbar disc disease susceptibility. Spine (Phila Pa 1976). 2014 Sep 15;39(20):1699-706. doi: 10.1097/BRS.0000000000000497.

6. Martirosyan NL, Patel AA, Carotenuto A, et al. Genetic Alterations in Intervertebral Disc Disease. Front Surg. 2016;3:59. Published 2016 Nov 21. doi:10.3389/fsurg.2016.00059.

7. Wu H, Wang S, Chen W, et al. Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis. J Orthop Surg Res. 2018;13(1):47. Published 2018 Mar 5. doi:10.1186/s13018-018-0750-0.

8. Berjano P, Villafañe JH, Lo Re D, Ismael M, Damilano M, Bertozzi L, Romanò CL, Drago L. Is Propionibacterium acnes related to disc degeneration in adults? A systematic review. J Neurosurg Sci. 2019 Apr;63(2):216-223. doi: 10.23736/S0390-5616.16.03842-X. Epub 2016 Sep 7.

9. Amin RM, Andrade NS, Neuman BJ. Lumbar Disc Herniation. Curr Rev Musculoskelet Med. 2017;10(4):507–516. doi:10.1007/s12178-017-9441-4.

10. Cramer G. Clinical Anatomy of the Spine, Spinal Cord, and ANS (Third Edition). 2014. Elsevier.

11. Cuesta A, Del Valle ME, García-Suárez O, et al. Acid-sensing ion channels in healthy and degenerated human intervertebral disc. Connect Tissue Res. 2014;55(3):197–204. doi.org/10.3109/03008207.2014.884083.

12. Kobayashi Y, Sekiguchi M, Konno S. Effect of an acid-sensing ion channels inhibitor on pain-related behavior by nucleus pulposus applied on the nerve root in rats. Spine (Phila Pa1976). 2017. doi.org/10.109/BRS.0b013e318173298b.

13. Liu J, Tao H, Wang H, et al. Biological behavior of human nucleus pulposus mesenchymal stem cells in response to changes in the acidic environment during intervertebral disc degeneration. Stem Cells Dev. 2017;26(12):901–11. doi.org/10.1089/scd.2016.0314.

14. Kim SG, Yang JC, Kim TW, Park KH. Spontaneous regression of extruded lumbar disc herniation: three cases report. Korean J Spine. 2013;10(2):78–81. doi:10.14245/kjs.2013.10.2.78.

15. Altun I, Yüksel KZ. Lumbar herniated disc: spontaneous regression. Korean J Pain. 2017;30(1):44–50. doi:10.3344/kjp.2017.30.1.44